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Day · Friday 4 December 2026
Second day of the seminar. It takes type 2 diabetes as a model problem to develop coordination failure, physiological permissions, insulin resistance, windows of reversal and therapeutic targets.
Benefits
Read type 2 diabetes as a problem of coordination across scales
Locate insulin resistance in the component of the system that sustains it
Recognise the windows in which a metabolic condition admits reversal
Identify the therapeutic targets the current arsenal leaves open
Apply the same reading to other chronic conditions
Session
Type 2 diabetes as a model problem
In type 2 diabetes the healthy state can be reached under forced intervention, and counter-regulation shows that the effectors respond: the machinery is there. The session takes the best-documented metabolic condition, reads it component by component and locates the failure in coordination rather than in capacity.
Failure profile by component: states and operators preserved; constraints, evaluation and horizon degraded
Evidence that the machinery is preserved: a reachable healthy state and active counter-regulation
Nine independent mechanisms that converge on coordination rather than on quantity
The three targets: intercellular coupling in the islet, hepato-vagal afference and the hypothalamic reference circuit
Session
Molecular mechanisms and therapeutic consequences
An effector can respond to a signal in one state and not in another without damage being involved. The session examines permissive signals through glucose disposal dependent on hepatic innervation.
Physiological permission and rigidified constraint: criteria for distinction, reversibility and differential diagnosis
Hepatic parasympathetic innervation: the permission that enables insulin-mediated glucose disposal without producing an effect of its own
Dependence on the fed state: the same insulin dose releases the signal after a meal but not during fasting
Dependence on route of entry: action abolished by denervation and recovered by intraportal, not intravenous, infusion
Permission closure during fasting and mechanisms distinguished by the observed response
A permission that stops activating after meals: a correct constraint in the wrong context and its reversibility
Session
Ratchets and windows of reversal
The state a system reaches rewrites what it is still permitted to do, and some of those rewritings are not undone when the state returns. The session orders the mechanisms documented in type 2 diabetes by whether they admit reversal and over what time frame.
Arrows from state to constraint: how the state reached changes what the system is permitted to do
Ratchet: what distinguishes a rewriting that can be undone from one that cannot
Ordering the mechanisms by reversibility and time window
Windows of reversal: from days to weeks, and those that depend on restoring a physiological cycle
The cost of merging mechanisms with different reversibility: recoverable targets given up as lost
Session
What the current arsenal does not address and which targets remain
Type 2 diabetes has one of the most complete arsenals in internal medicine and remains progressive. The session examines what is left unaddressed when treatment is ordered by the component it repairs, and which strategies follow from that reading.
What routine monitoring measures: the glucose level reached, not the capacity to regulate it
Continuous exposure versus pulsatile exposure anchored to meals
Targets by component: anticipatory response, intercellular coupling in the islet and microbiota
Combination criterion: covering different points of the failure rather than adding effect on the same one
Regulation programmes built from the quintuple: pharmacological and non-pharmacological interventions ordered by the component they repair
Carrying the reading over to other chronic conditions: dyslipidaemia, metabolic syndrome and the thyroid axis
Venue
Hotel Galería Plaza Reforma, Mexico City
Hours
10:00 to 18:00
Format
In person and online, with live streaming
Fees
Available via WhatsApp
Enquiries
Request information on WhatsApp
+52 55 7907 6626 · contacto@institutocentrobioenergetica.com
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Instituto Centrobioenergetica · Mexico City
Diverse Cognition 2026